It is well known that the combination of hyepertension and hyperlipidemia is the perfect receipe for

arteriosclerosis and the resulting consequences including coronary artery disease, vascular dementia, and others.

The so called small vessel disease of the brain white matter is rather common among the elderly when 

they undergo the MRI of brain.

In the span of 43 some years in my clinical practice, I have had chances to follow

a good number of patients for decades.

Even in the absence of a significant hypertension, I was impressed by the predictability

of hyperlipidemia causing vascular dementia in late life. It seems less than ideal control of hyperlipidemia,

especially the familial hypercholesterolemia,

appears to predict the late life vascular dementia.