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Clinicians have long suspected this, and
now we have a good evidence for it.
It's always been a good practice to use a combination
of more than one drug instead of increasing the dosage
of one drug to the maximum which increases the chances
of side effects.
Polypharmacy in treating hypertension of different severity
makes a good medical sense when we realize that the cause of
hypertension is multifactorial and requires more than one intervention
in its pathophysiology.