2021.09.22 14:22
https://www.nytimes.com/2021/09/22/health/covid-moderna-pfizer-vaccines.html
Moderna vaccine is superior to Pfizer's in long-term efficacy in the latest studies published.
2021.09.22 14:25
2021.09.22 14:31
https://www.nejm.org/doi/full/10.1056/NEJMoa2106599
The original article mentioned in the above text.
2021.09.22 17:13
Yes, I was also a bit disappointed with the Pfizer vaccine!
Then, how much the third/booster shot would improve the long-term outcome/efficacy of Pfizer?
Can it reach the level of Moderna?
BB Lee
2021.09.22 17:28
As you heard, the short-term result of Pfizer booster in Israel was said to be
"fantastic ", which was reported in this space.
We will be more interested in hearing longer-term efficacy, especially in the elderly.
I'm sure we will hear a lot more.
So far, the data among the elderly have been lumped together as 65 and older
or 55 and older, the age breakdown in all the reports has been less than satisfactory
to say the least. For example, there is no information on efficacy for 80 and older.
As a consequence, you and I have to do educated guesswork to reach some tentative number.
At any rate, we all seniors in this country are lucky to have the good fortune
to be well protected and have nothing to complain about, I feel.
2021.09.22 18:49
Couldn't agree more, doc!
We are simply lucky despite these many human garbages to annoying us more and more!
God bless America!
BB Lee
2021.09.23 06:49
The third shot will definitely enforce and strengthen our immunity according to the Israel study.
Please don't pay too much attention to these stupid noises and get confused about the basic truth.
We should depend on the principle of immunology, not on this shaky commercial propaganda
by the enemies of Pfizer. We should realize that the researchers are on a minimum salary
and they can be easily persuaded by the big money. To a certain degree, we should rely on our own
integrity on a subject like this. Only truth comes from further studies and experiences we accumulate
in the long run. At this time, we do not know much about Kovid-19. We are just in the stage of a kid.
Addendum: On today's news,
"The FDA authorization allows a booster dose administered six months
after the second shot of the Pfizer vaccine for people 65 and older, or in high-risk groups."
Let them keep talking trash. What's the fuxxxxx difference between 6 months and 8 months?
How, in the world, does the FDA know so clearly?? At the current stage of the game on Kovid-19,
Joe Biden's wild guess is as good as that of FDA or CDC. ...My opinion.
2021.09.23 19:42
BTW, Dr. HJ, could you share the literatures involved to the dispute over 6 months versus 8 month, as WM raised? Isn't that based on the amount of leftover/remaining antibodies or actual memory status of B cells or else?
BB Lee
2021.09.23 20:41
Here is one review in the below
https://www.newsweek.com/science-data-behind-covid-19-booster-shots-explained-1620715
2021.09.24 07:16
Thanks!!!
So, this decision is pretty much based on the epidemiological data of breakthrough infection among the vaccinated peoples and the antibody level/titers wasn't much involved in this decision, disappointingly!
BB Lee
P.S. BTW, Dr. HJ, how much this booster effect would last? Is there any information? Any speculation or anticipation?
2021.09.24 07:49
That is a critically important question the whole world needs to know.
Probably Israel will have answer in time since they started the booster shots first.
As of now, I don't believe there is any information other than the fact that
there was many fold increase in antibody titer with boosters which we hope
last for lifetime.
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"The latest such study, published on Wednesday in The New England Journal of Medicine, evaluated the real-world effectiveness of the vaccines at preventing symptomatic illness in about 5,000 health care workers in 25 states. The study found that the Pfizer-BioNTech vaccine had an effectiveness of 88.8 percent, compared with Moderna’s 96.3 percent.
Research published on Friday by the Centers for Disease Control and Prevention found that the efficacy of the Pfizer-BioNTech vaccine against hospitalization fell from 91 percent to 77 percent after a four-month period following the second shot. The Moderna vaccine showed no decline over the same period."