2017.04.21 11:09
Published in Cardiology
Journal Scan / Research · April 20, 2017
This study used coronary computed tomography angiography (CTA) to determine the association of temporal changes in coronary plaque volume with intensity of lipid-lowering treatments. Elevated LDL-C levels (≥70 mg/dl) were associated with increased plaque progression over the median 3.2-year follow-up.
The results indicate that intensive LDL-C control improves plaque volume and may provide greater benefit than less strict LDL-C control in patients with atherosclerosis.
This abstract is available on the publisher's site.
Access this abstract nowThe aim of this study was to explore the relationship between temporal changes in coronary plaque volume and the intensity of lipid-lowering treatments, utilizing coronary computed tomography angiography (CTA).
Coronary CTA has acceptable accuracy in terms of quantitative measurement of plaque volume. Although, coronary CTA is perhaps capable of identifying the differences in plaque volume progression according to the intensity of lipid lowering treatment, to date, few studies have examined this notion.
In this multicenter, observational study, the authors reviewed 467 patients who underwent serial coronary CTA with a scan period of more than 2 years (median 3.2 years [2.4 to 4.8]) apart, and whose laboratory data were available within 1 month of both the baseline and follow-up coronary CTA. Among them, 147 patients (comprising 336 vessels) with visible plaque were enrolled in this study. The authors performed quantitative assessment of coronary plaque in both. Patients who achieved a low-density lipoprotein cholesterol (LDL-C) with a cut off value below 70 mg/dl at follow-up were compared with those who did not.
Patients with LDL-C below 70 mg/dl displayed a significant attenuation in plaque progression as compared with those with follow-up LDL-C levels ≥70 mg/dl (12.7 ± 38.2 mm(3) vs. 44.2 ± 73.6 mm(3), respectively; p = 0.014). In multivariate analysis, factors influencing plaque progression per year was follow-up LDL-C levels ≥70 mg/dl (beta 0.193; p = 0.021).
Strict LDL-C control appeared to significantly attenuate plaque volume progression based on noninvasive quantitative assessment by coronary CTA.
No. | Subject | Date | Author | Last Update | Views |
---|---|---|---|---|---|
Notice | How to write your comments onto a webpage [2] | 2016.07.06 | 운영자 | 2016.11.20 | 18185 |
Notice | How to Upload Pictures in webpages | 2016.07.06 | 운영자 | 2018.10.19 | 32334 |
Notice | How to use Rich Text Editor [3] | 2016.06.28 | 운영자 | 2018.10.19 | 5908 |
Notice | How to Write a Webpage | 2016.06.28 | 운영자 | 2020.12.23 | 43827 |
8042 | 2010년 4월 18일 서울 나들이 [3] | 2010.04.19 | 계기식*72 | 2010.04.19 | 8394 |
8041 | La Sagrada Familia by Antoni Gaudi (1) [4] | 2011.05.06 | 이기우*71문리대 | 2011.05.06 | 8392 |
8040 | 그리운 사람이 있다는 것은 / 조병화 [7] | 2011.02.11 | 황규정*65 | 2011.02.11 | 8391 |
8039 | ♥ 뇌졸중 -1 [1] | 2009.08.11 | 이종구*57 | 2009.08.11 | 8391 |
8038 | London에서 하루 [3] | 2009.10.11 | 유석희*72 | 2009.10.11 | 8390 |
8037 | 화왕산-관룡산을 애견과 함께 | 2009.09.30 | 유석희*72 | 2009.09.30 | 8387 |
8036 | 스위스여행 #3. 6-27 (취맄-생모리츠-베르니나특급 2) [2] | 2010.07.15 | 계기식*72 | 2010.07.15 | 8385 |
8035 | 서울대 소식 (12-03-2009) [1] | 2009.12.14 | 운영자 | 2009.12.14 | 8385 |
8034 | 법정 스님의 마즈막 유언 전문 [1] | 2010.03.17 | 운영자 | 2010.03.17 | 8382 |
8033 | [LPGA] 서희경 KIA Classic 우승 [6] | 2010.03.28 | 황규정*65 | 2010.03.28 | 8375 |
8032 | [FIFA] World Cup 2010 - 이모 저모 [2] | 2010.07.04 | 운영자 | 2010.07.04 | 8372 |
8031 | 여자 쇼트트랙 1500m, 이은별 銀, 박승희 銅 [2] | 2010.02.21 | 황규정*65 | 2010.02.21 | 8370 |
8030 | ♥ 신형 혈관확장제(Darusentan)가 난치성 고혈압에 효과적 | 2010.08.25 | 이종구*57 | 2010.08.25 | 8369 |
8029 | 이해인 수녀님 특강 [7] | 2010.01.24 | 황규정*65 | 2010.01.24 | 8367 |
8028 | This is WAR (3), 1951 [10] | 2010.06.19 | 한원민*65 | 2010.06.19 | 8365 |
8027 | Greetings from 윤원길 [4] | 2006.12.26 | 一水去士 | 2016.06.17 | 8363 |
8026 | 눈 내리는 2010년 4월 13일 대한민국 [5] | 2010.04.13 | 계기식*72 | 2010.04.13 | 8362 |
8025 | Long comments moved here [re] Road to Instanbul [8] | 2010.10.21 | 민경탁*65 | 2010.10.21 | 8359 |
8024 | [스위스 여행기] (2)[Jungfrau산 관광] | 2009.11.07 | 심영보*61 | 2009.11.07 | 8359 |
8023 | [LPGA] 신지애 LPGA 미즈노클래식 우승, 시즌 2승째 [4] | 2010.11.06 | 황규정*65 | 2010.11.06 | 8358 |