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The Importance Of Non-HDL Cholesterol

 

    Non-HDL Cholesterol
    (Non-HDL-C=total cholesterol minus HDL-C)
    has been shown to be a better marker of risk
    in both primary and secondary prevention studies
    than LDL cholesterol.
    In a recent analysis of data combined from
    68 studies by Di Angelantonio et al,
    non-HDL-C was the best predictor among
    all cholesterol measures, for both CAD events
    and for strokes.

    Non-HDL-C, unlike LDL-C, represents
    the cholesterol content present in all the atherogenic
    lipoproteins which include LDL-C, VLDL-C,
    IDL-C and Lp(a) cholesterol.

    The treatment goal for non-HDL-C is 30 mg/dl
    above the LDL-C treatment target.
    For example, if the LDL-C treatment goal is
    less than 70 mg/dl, the non-HDL-C treatment target
    would be less than 100 mg/dl.

    It has been shown(PROVE-IT TIMI 22 Trial) that
    the risk for future coronary artery disease(CAD)events
    remains high(22.7% of the patients had a recurrent event
    at 2 years of follow-up despite attaining LDL-C levels
    of 67 mg /dl and receiving optimal medical care.).

    Elevated non-HDL-C in combination with normal levels
    of LDL-C identify a subset of patients with elevated levels
    of LDL particle number, elevated apo B concentrations,
    and LDL of small, dense morphology.

     ㅡ Reference review article: "Non-HDL Cholesterol as a Metric of
    Good Quality of Care. Salim S Virani, Texas Heart Institute J,
    Volume 38, Number 2, April 2011"

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