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Physical Exercise as a Preventive


or Disease-Modifying Treatment of
Dementia and Brain Aging,
J. Eric Ahllskog, PhD, MD, et al,
Mayo Clinic Proceedings,
2011;86(9):876-884


      A rapidly growing literature strongly suggests
      that exercise, specifically aerobic exercise,
      may attenuate cognitive impairment and
      reduce dementia risk. ....
      Meta-analysis of prospective studies
      documented a significantly reduced risk of
      dementia associated with midlife exercise;
      similarly, midlife exercise significantly reduced
      later risk of mild cognitive impairment
      in several studies.

      Among patients with dementia or mild
      cognitive impairment, randomized controlled
      trials documented better cognitive scores
      after 6 to 12 months of exercise compared
      with sedentary controls.
      Meta-analyses of randomized controlled
      trials of aerobic exercise in healthy adults
      were also associated with significantly
      improved cognitive scores.

      One year of aerobic exercise in a large
      randomized controlled trial of seniors was
      associated with significantly larger hippocampal
      volumes and better spatial memory;
      other randomized contolled trials in seniors
      documented attenuation of age-related
      gray matter volume loss with aerobic exercise.
      Cross-sectional studies similarly reported
      significantly larger hippocampal or gray matter
      volumes among physically fit seniors compared
      with unfit seniors.

      Brain cognitive networks studied with functional
      MRI display improved connectivity after 6 to 12
      months of exercise.
      Animal studies indicate that exercise facilitates
      neuroplasticity via a variety of biomechanisms,
      with improved learning outcomes.
      Induction of brain neurotrophic factors by
      exercise has been confirmed in multiple animal
      studies, with indirect evidence for this process
      in humans.

      Besides a brain neuroprotective effect,
      physical exercise may also attenuate cognitive
      decline via mitigation of cerebrovascular risk,
      including the contribution of small vessel disease,
      to dementia.
      Exercise should not be overlooked as an
      important therapeutic strategy.

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