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This is an important information for all the people who
are taking hypertension medications.
Based on the so called circadian rhythm many cardiologists have been
advising their patients to take the antihypertensives, particularly potent ones,
at bed time to help prevent the cardiovascular complications that usually occur
between 3 AM and 11 AM.
This study indicates that you can reduce the incidence almost by half and
confirms the importance of the practice.
"Day-night variations in blood pressure (BP) and heart rate (HR) are among the best known circadian rhythms of physiology. In humans, there is a 24-h variation in BP with a sharp rise before awakening, the highest BP value is around midmorning (Millar-Craig et al., 1978). Concomitantly, many cardiovascular events, such as sudden cardiac death, myocardial infarction and stroke, display diurnal variations with an increased incidence in the morning (Muller et al., 1985, 1987; Elliott, 1998;"(from Internet)
https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41569-019-0167-4&data=02%7C01%7C%7C37dd78844e66478b87ca08d758cc1027%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637075505773162028&sdata=AJimoH2NAuhnZw2qGwyf9AHn8bcLZIx2Boq6Za%2BoAtQ%3D&reserved=0